WAINUA

Starts Reducing TTR Protein Quickly and Continues to Keep TTR Low Between Doses

In a clinical study, blood levels of TTR protein levels were first measured at Week 5. WAINUA lowered TTR protein to 50% from the starting level (baseline) by Week 5, with an 81% decrease from baseline by Week 35. Patients received WAINUA at Week 1 and once every 4 weeks thereafter. Blood levels of TTR protein were measured before the next dose was given, except at Week 35, when it was measured between doses.

Your results may vary.

Watch this video to learn more about how WAINUA works.

In a clinical study, blood levels of TTR protein levels were first measured at Week 5. WAINUA lowered TTR protein to 50% from the starting level (baseline) by Week 5, with an 81% decrease from baseline by Week 35. Patients received WAINUA at Week 1 and once every 4 weeks thereafter. Blood levels of TTR protein were measured before the next dose was given, except at Week 35, when it was measured between doses.

Your results may vary.

hATTR Symptoms Start with Unstable TTR Proteins

The transthyretin protein

(TTR) carries vitamin A and thyroid hormones throughout the body. In people with hATTR, the unstable TTR protein breaks apart, misfolds, and forms amyloid fibrils that can build up and cause damage throughout the body.

This Is How WAINUA Works:

How WAINUA WorksHow WAINUA Works mobile

WAINUA works within the liver, where TTR is made,

to lower the production of TTR protein,

which results in fewer
amyloid deposits throughout your body.

Support Resources for hATTR-PN and WAINUA

Find Everything You Should Know About hATTR-PN and WAINUA, Including Support Resources, in One Place.

Download the WAINUA Brochure 

The Who, What, When, and How of hATTR-PN

Hereditary ATTR Amyloidosis

How WAINUA Can Help Stop Further hATTR-PN Progression

See Results for hATTR-PN

Important Safety Information

WAINUA may cause side effects, including:

Low vitamin A level, which is a serious, but common side effect of treatment with WAINUA. Your doctor should tell you to take vitamin A supplements. Do not take more than the amount of vitamin A your doctor has recommended. Call your doctor if you develop eye problems such as difficulty seeing at night or in low-lit areas (night blindness), or dry eyes. If you develop eye problems, your doctor should refer you to an eye doctor

APPROVED USES

WAINUA injection, for subcutaneous use, 45 mg is a prescription medicine used to treat adults with polyneuropathy of hereditary transthyretin-mediated amyloidosis.

The most common side effects include decreased vitamin A and vomiting.

Before you take WAINUA, tell your healthcare provider:

  • if you are pregnant or breastfeeding, or plan to become pregnant or breastfeed. It is not known if WAINUA can harm your baby. Changes in vitamin A levels and vitamin A supplementation related to use of WAINUA may harm your unborn baby. It is not known if WAINUA passes into breast milk
  • about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take vitamin A or beta-carotene supplements

APPROVED USES

WAINUA injection, for subcutaneous use, 45 mg is a prescription medicine used to treat adults with polyneuropathy of hereditary transthyretin-mediated amyloidosis.

Please see full Prescribing Information, including Patient Information.

You may report side effects related to AstraZeneca products.

Important Safety Information

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