About hATTR-PN
Hereditary ATTR (hATTR) amyloidosis is an inherited condition caused by the misfolding of transthyretin protein (also known as TTR). TTR is a protein made primarily in the liver that carries vitamin A and thyroid hormones throughout the body. In people with hATTR, unstable TTR protein breaks apart, misfolds, and forms amyloid fibrils that can build up and cause damage throughout the body.
hATTR is passed down through family members (genetically inherited). If one parent has hereditary ATTR amyloidosis, there is a 50% chance their child will inherit the mutation (or variant). However, not everyone who inherits the mutation will go on to develop the symptoms of hATTR amyloidosis.
hATTR symptoms can vary from person to person. The amyloid deposits caused by hATTR amyloidosis cause illness by damaging the structure and the functions of the organs where they are found. It can affect your nervous system, digestive system, and heart.
Symptoms of hATTR can seem unrelated, as amyloids can deposit in various tissues and organs throughout the body and present as more common conditions, making it difficult to diagnose.
For more information about symptoms, visit the hereditary ATTR amyloidosis page.
Because hATTR amyloidosis can affect many parts of the body, you may see several different specialists, including neurologists, gastroenterologists, and cardiologists.
Diagnosis can be difficult because the symptoms of hATTR can be similar to those of other, more common conditions. Because it is a hereditary condition, genetic tests can help you and your doctor find the correct diagnosis.
About WAINUA
WAINUA is a treatment for polyneuropathy caused by hereditary ATTR amyloidosis (hATTR-PN). It works within the liver to lower the production of the TTR protein, which results in fewer amyloid deposits throughout the body.
The most common side effects include decreased vitamin A and vomiting.
WAINUA may cause low vitamin A level. Low vitamin A level is a serious, but common side effect of treatment with WAINUA. Your healthcare provider should tell you to take vitamin A supplements while using WAINUA. Do not take more than the amount of vitamin A your healthcare provider has recommended. Call your healthcare provider if you develop eye problems such as difficulty seeing at night or in low-lit areas (night blindness), or dry eyes. If you develop eye problems while receiving treatment with WAINUA, your healthcare provider should send you to see an eye doctor (ophthalmologist).
These are not all the possible side effects of WAINUA. Talk to your healthcare provider about side effects that you experience.
WAINUA is approved to treat polyneuropathy caused by hATTR amyloidosis in adults.
It’s important to make sure you have the information you need when considering your treatment options. Here are a few questions to help you get started:
- How does WAINUA work?
- How will I know if it’s working?
- How do I take WAINUA?
If you would like some help preparing for your next doctor appointment, download this helpful guide.
WAINUA may affect vitamin A levels in your body. Let your doctor know if you are taking any vitamin A supplements—along with any other medications or supplements you are taking.
You should also let your doctor know if you are pregnant, intend to become pregnant, or are breastfeeding before starting treatment with WAINUA.
WAINUA works within the liver to lower the production of TTR protein right away, but the effects of that suppression may take time and vary between individuals. Speak with your doctor about how WAINUA may work for you.
Individual results may vary. Click below to learn more about WAINUA's effects on neuropathy progression and quality of life.
Before beginning treatment with WAINUA, let your healthcare provider know all the medications you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements, especially if you’re taking any vitamin A or beta-carotene supplements, as WAINUA may affect your vitamin A levels.
Click below to learn more about the safety and side effects of WAINUA.
There are no dietary restrictions when taking WAINUA. Speak to your healthcare provider or a nutritionist if you would like recommendations for supplementing your vitamin A levels.
Taking WAINUA
WAINUA comes in an autoinjector, a self-injectable device that allows you to deliver the right dose of medication. The actual injection takes just 10 seconds, once monthly. You can take it at home or on the go.
Yes. Whether you take WAINUA by yourself or with help, the steps are the same. Watch our instructional video for more information.
Your autoinjector and sharps container will be mailed to you by a specialty pharmacy. They might call or text to schedule your delivery. Enroll in the WAINUA WAY support program for a welcome kit with helpful tools to get you started.
Do not use a damaged autoinjector. Call 1-844-2-WAINUA (1-844-292-4682) for a replacement.
Your autoinjector will arrive in a cooler, but you can store it at room temperature—up to 86 °F (30 °C)—for up to 6 weeks. It can also be stored in the refrigerator at 36 °F to 46 °F (2 °C to 8 °C). Keep it in the carton until you use it.
Always discuss travel with your healthcare provider first. You can travel with your autoinjector if you store it as described in the Patient Information and Instructions for Use.
If you miss a dose, take the missed dose as soon as possible. Then take WAINUA 1 month from the date of your last dose to get back on a monthly dosing schedule. If you have questions about your schedule, ask your healthcare provider.
Savings & Support
The cost varies based on each person’s unique financial situation. People prescribed WAINUA can reach out to AstraZeneca Access 360™ for information on cost and savings options. If you have commercial insurance, you may be able to pay as little as $0 for WAINUA through the WAINUA Savings Program.
There are a variety of financial assistance programs available. AstraZeneca Access 360™ can help you learn which programs you may be eligible for. You could be eligible for support even if you don’t have insurance coverage or have been denied insurance coverage.
You should always contact your healthcare provider with any questions. You can also connect with a Patient Education Manager, who can be your dedicated point of contact for ongoing support throughout your WAINUA treatment.
Your Patient Education Manager can:
- Give you information about hATTR-PN and WAINUA
- Provide updates during the insurance approval process
- Share resources on how to take WAINUA
